- Not related to your issue you should set your GUI resolution to 1080p (see below)
- you are using NFS (good) but you are using the Kodi internal NFS implementation which can give performance issues so you might want to try kernel based mounting (see below)
Is that with all files or only this specific file?
Kernel Mounts
GUI Resolution
We recommend people with 4K TVs set their user interface (UI) to 1080p. Kodi’s UI is not optimized for 4K yet and this can put unnecessary demands on your device and can lead to a suboptimal picture quality, as well as potentially cause other issues.
The settings we recommend are as follows…
Settings>System>Display>Resolution> 1920x1080p
Settings>System>Display>Whitelist> (empty) *
Settings>Player>Videos>Adjust display refresh rate>Always
Some televisions may also need, or benefit from, the following being set…
System>Display>Force 4:2:2 colour subsampling> (enable)
With the above settings your UI will be output in Full HD and your 4K content will be output in 4K.
*Information regarding the whitelist can be found here. If you have any doubt, feel free to upload some logs so we can verify that your settings are indeed correct.