This remote appears to the operating system as a regular keyboard and mouse and which keys are sent depends on which version of the remote you have. How the keys are assigned can be found [HERE]. I have not previously ventured into this kind of thing in Windows but a cursory search led me to a program called AutoHotkey and if it was me I think that is where I would start. It may not fully check off the “easiest” requirement but it works with both keyboards and mice and it allows for per-application assignments so you can make buttons work the same with different players that use different keyboard shortcuts.
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