Definitely won’t be a problem, even over 5Ghz WiFi. Wired is preferred if you can run it, but not a necessity.
From the top of my head Aeon Nox is a pretty intense skin. Running it at 4K will also use more resources, which is why we keep the default at 1080p for now.
We also keep it at 1080p because there are some problems if you use whitelisting for video with 4K modes. But if you don’t use this feature it should be OK.
It would be hard to advise whether it’s going to be performant enough for you. I know of one user @Frido running it on his device and he said it was running great:
Maybe some others could test or advise you further