Sorry @sam_nazarko but for the first time I have to disagree with you, for several months I played untouched UHD rips on my Vero 4K from a NTFS hdd , in fact from several hdd’s in a setup very similar to @Kontrarian described (Seagate backup plus with 2 more drives plugged into its two USB ports) without an issue.
I had no stuttering, no buffering and seek worked perfectly, the only thing I changed from out of the box setups on the hdd’s was using a different USB 3 cable on the Seagate to the one which came with it, the supplied cable limited that drive to a maximum of 30 MB/s on file transfers within my Windows 10 environment whereas a different cable yielded about 170 MB/s